炎症在推动 pre-HFpEF 模型左心室重构中的作用。
The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model.
机构信息
Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico 07738, Mexico.
Department of Histopathology, School of Medicine, Universidad Panamericana, Ciudad de Mexico 03920, Mexico.
出版信息
Exp Biol Med (Maywood). 2020 Apr;245(8):748-757. doi: 10.1177/1535370220912699. Epub 2020 Mar 17.
Abstract
The incidence of HFpEF continues to increase and ∼2/3 of the patient population are post-menopausal women. Unfortunately, most studies focus on the use of male animal models of remodeling. In this study, however, using female rats to set a model of pre-HFpEF, we provide insights to possible mechanisms that contribute to HFpEF development in humans that will lead us to a better understanding of the underlying pathophysiology of HFpEF.
摘要
HFpEF 的发病率持续上升，约 2/3 的患者人群为绝经后妇女。不幸的是，大多数研究都集中在使用雄性动物重塑模型上。然而，在这项研究中，我们使用雌性大鼠建立了 pre-HFpEF 模型，为可能导致 HFpEF 发生的人类机制提供了新的认识，这将有助于我们更好地理解 HFpEF 的潜在病理生理学。
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