Owen P, Pendlebury A, Moffat A C
J Chromatogr. 1978 Nov 21;161:187-93. doi: 10.1016/s0021-9673(01)85226-2.
The efficiencies of fifteen thin-layer silica gel chromatographic systems for separating commonly encountered neutral drugs are compared. The discriminating powers of the systems are measured both individually and in combination. Chloroform-acetone (4:1) is found to be the best system. The combination of the ethyl acetate-methanol-ammonia (85:10:5) system with this gives the best pair of systems. A suitable sequence of spray reagents is also suggested. The chloroform-acetone (4:1) system is recommended as the best system to use when screening for both acidic and neutral drugs.
比较了15种用于分离常见中性药物的薄层硅胶色谱系统的效率。分别测定了这些系统的鉴别能力，并将它们组合起来进行测定。发现氯仿 - 丙酮（4:1）是最佳系统。将乙酸乙酯 - 甲醇 - 氨（85:10:5）系统与该系统组合可得到最佳的系统对。还建议了合适的喷雾试剂顺序。推荐氯仿 - 丙酮（4:1）系统作为筛选酸性和中性药物时的最佳使用系统。
