Ogasawara Kosuke
Medical Corporation, Ogasawara Eye Clinic, Morioka Iwate 020-0114, Japan.
Clin Ophthalmol. 2020 Mar 3;14:635-642. doi: 10.2147/OPTH.S246731. eCollection 2020.
To measure marginal reflex distance-1 (MRD-1) values in normal subjects and patients with blepharoptosis using second-generation swept-source anterior segment optical coherence tomography (AS-OCT) and to evaluate the usefulness of this measurement method.
MRD-1 values were measured using AS-OCT in 80 eyes of 40 normal subjects (16 men and 24 women) aged 20-59 years with no neurological or endocrinological disorders, and the measured values were compared between four age groups comprising 20 eyes of 10 subjects each in their 20s, 30s, 40s, and 50s. The Volk Eye Check system was simultaneously used to measure MRD-1 in 40 eyes of 20 normal subjects, and the measured values were compared with those obtained using AS-OCT. In 21 eyes of consecutive 13 involutional blepharoptosis patients (48-84 years of age, mean 70.2 years), MRD-1 values were measured using AS-OCT preoperatively and 3 months after surgery to examine the rates of successful measurements as well as preoperative and postoperative results.
The mean MRD-1 value using AS-OCT in 80 eyes of 40 normal subjects was 3.70 ± 0.10 mm, whereas the values in 20 eyes of 10 subjects each from the four different age groups were 4.01 ± 0.54 mm, 3.88 ± 0.60 mm, 3.96 ± 0.77 mm, and 2.94 ± 0.79 mm for subjects in their 20s, 30s, 40s, and 50s, respectively; significant differences were observed between the 50s group and other groups (p<0.01). The mean MRD-1 values using AS-OCT and the Volk Eye Check system in 40 eyes of 20 normal subjects were 3.68 ± 0.70 mm and 3.71 ± 0.84 mm, respectively, with no significant differences (p:0.87). The mean preoperative and postoperative MRD-1 values in patients with involutional blepharoptosis were 0.29 ± 0.70 mm and 3.24 ± 0.92 mm, respectively; the rate of successful MRD-1 measurements using AS-OCT was 100% among trial subjects.
MRD-1 measurement using AS-OCT is a simple and reproducible method that allows the direct comparison of numerical values in normal subjects as well as in patients with blepharoptosis.
使用第二代扫频源眼前节光学相干断层扫描（AS-OCT）测量正常受试者和上睑下垂患者的边缘反射距离-1（MRD-1）值，并评估该测量方法的实用性。
使用AS-OCT对40名年龄在20-59岁、无神经或内分泌疾病的正常受试者（16名男性和24名女性）的80只眼睛进行MRD-1值测量，并将测量值在四个年龄组之间进行比较，每个年龄组包括10名受试者的20只眼睛，分别为20多岁、30多岁、40多岁和50多岁。同时使用Volk Eye Check系统对20名正常受试者的40只眼睛进行MRD-1测量，并将测量值与使用AS-OCT获得的值进行比较。对连续13例年龄在48-84岁（平均70.2岁）的退行性上睑下垂患者的21只眼睛，术前和术后3个月使用AS-OCT测量MRD-1值，以检查成功测量率以及术前和术后结果。
40名正常受试者的80只眼睛使用AS-OCT测量的平均MRD-1值为3.70±0.10mm，而四个不同年龄组中每组10名受试者的20只眼睛的测量值分别为：20多岁的受试者为4.01±0.54mm，30多岁的受试者为3.88±0.60mm，40多岁的受试者为3.96±0.77mm，50多岁的受试者为2.94±0.79mm；50多岁组与其他组之间观察到显著差异（p<0.01）。20名正常受试者的40只眼睛使用AS-OCT和Volk Eye Check系统测量的平均MRD-1值分别为3.68±0.70mm和3.71±0.84mm，无显著差异（p=0.87）。退行性上睑下垂患者术前和术后的平均MRD-1值分别为0.29±0.70mm和3.24±0.92mm；在试验对象中，使用AS-OCT成功测量MRD-1的比率为100%。
使用AS-OCT测量MRD-1是一种简单且可重复的方法，能够直接比较正常受试者以及上睑下垂患者的数值。
