Ebbesen F, Hess J, Brodersen R
Department of Paediatrics, University Hospital of Glostrup, Denmark.
Acta Obstet Gynecol Scand. 1988;67(5):405-9. doi: 10.3109/00016348809004249.
The purpose of this study was to investigate the binding potential of MADDS (monoacetyldiaminodiphenyl sulphone) to albumin, a measure for binding of unconjugated bilirubin, in healthy women during pregnancy, during and after delivery, and in their infants. The serum concentrations of unconjugated bilirubin, reserve albumin for binding of MADDS and total albumin were measured in: (a) 21 non-pregnant women; (b) 16 pregnant women in the 16th-24th, 28th-32nd, and 36th-38th gestational weeks, and at the time of delivery from both mother and infant; and (c) 15 women at the time of delivery, and 24 and 72 hours after delivery. The bilirubin concentrations did not change during pregnancy or at delivery and were very small compared with the concentrations of reserve albumin for binding of MADDS and total albumin. Therefore, the ratio of reserve albumin to total albumin was an expression of the binding potential of the albumin for MADDS in women. During pregnancy, the reserve albumin decreased equal to total albumin, so that the ratio was not significantly changed (p greater than 0.05). In contrast, at delivery the reserve albumin was significantly lower (p less than 0.01) than in the 36th-38th gestational weeks, without any significant difference in total albumin, i.e. the ratio was significantly lower than during pregnancy (p less than 0.01). During the first 3 days after delivery the reserve albumin increased significantly (p less than 0.05), also without any significant change in total albumin, so that the ratio increased significantly (p less than 0.05) and was normalized. The binding potential for MADDS to albumin in newborn infants was even lower than that of their mothers. Since the binding-potential is reduced in both mother and infant at delivery, a relation is suggested.
本研究的目的是调查单乙酰二氨基二苯砜（MADDS）与白蛋白的结合潜力，白蛋白是未结合胆红素结合能力的一种衡量指标，研究对象为孕期、分娩期间及产后的健康女性及其婴儿。测定了以下人群血清中未结合胆红素、MADDS结合储备白蛋白及总白蛋白的浓度：（a）21名未孕女性；（b）16名分别处于妊娠第16 - 24周、28 - 32周、36 - 38周的孕妇，以及母婴分娩时的样本；（c）15名产妇在分娩时、产后24小时及72小时的样本。孕期及分娩时胆红素浓度未发生变化，与MADDS结合储备白蛋白及总白蛋白的浓度相比非常低。因此，储备白蛋白与总白蛋白的比值可反映女性白蛋白对MADDS的结合潜力。孕期，储备白蛋白与总白蛋白同步下降，故该比值无显著变化（p＞0.05）。相反，分娩时储备白蛋白显著低于妊娠36 - 38周时（p＜0.01），而总白蛋白无显著差异，即该比值显著低于孕期（p＜0.01）。产后前3天储备白蛋白显著升高（p＜0.05），总白蛋白无显著变化，致使该比值显著升高（p＜0.05）并恢复正常。新生儿白蛋白对MADDS的结合潜力甚至低于其母亲。由于母婴在分娩时结合潜力均降低，提示二者存在关联。
