Ebbesen F, Foged N, Brodersen R
Acta Paediatr Scand. 1986 Jul;75(4):550-4. doi: 10.1111/j.1651-2227.1986.tb10248.x.
The reserve albumin concentration for binding of MADDS (monoacetyldiaminodiphenyl sulphone) in plasma is used as a measure of the reserve albumin concentration for binding of unconjugated bilirubin. The aim of the present study was to investigate whether a reduction in the reserve albumin concentration for binding of MADDS could exist in sick children after 5 months of age, where the bilirubin binding properties of the albumin has reached the adult level. The material included 75 children, 1-15 years of age with mild infections, severe bacterial infections, acute viral hepatitis, chronic hepatic diseases or uraemia, and a control group of 22 healthy children. The reserve albumin concentration was significantly lower in children with severe bacterial infections, acute viral hepatitis, and uraemia, than in healthy children (p less than 0.01), while the reserve albumin concentration in children with mild infections and chronic hepatic diseases did not differ significantly from that of the control group (p greater than 0.05). The total albumin concentration in plasma in either of the groups of sick children did not differ significantly from that of the healthy children. The plasma concentration of unconjugated bilirubin was elevated in the group of children with acute viral hepatitis, but not enough to influence the concentration of reserve albumin for binding of MADDS to a significant degree. The reserve albumin concentration was significantly lower in children with acute viral hepatitis than in children with severe bacterial infections (p less than 0.05).
血浆中用于结合单乙酰二氨基二苯砜（MADDS）的储备白蛋白浓度被用作衡量未结合胆红素结合储备白蛋白浓度的指标。本研究的目的是调查5个月龄以上患病儿童是否存在MADDS结合储备白蛋白浓度降低的情况，此时白蛋白的胆红素结合特性已达到成人水平。研究材料包括75名1至15岁患有轻度感染、严重细菌感染、急性病毒性肝炎、慢性肝病或尿毒症的儿童，以及22名健康儿童组成的对照组。患有严重细菌感染、急性病毒性肝炎和尿毒症的儿童的储备白蛋白浓度显著低于健康儿童（p<0.01），而患有轻度感染和慢性肝病的儿童的储备白蛋白浓度与对照组无显著差异（p>0.05）。患病儿童组中任何一组的血浆总白蛋白浓度与健康儿童相比均无显著差异。急性病毒性肝炎患儿组中未结合胆红素的血浆浓度升高，但不足以显著影响MADDS结合储备白蛋白的浓度。急性病毒性肝炎患儿的储备白蛋白浓度显著低于严重细菌感染患儿（p<0.05）。
