Esbjörner E
Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
Acta Paediatr Scand. 1991 Apr;80(4):400-5. doi: 10.1111/j.1651-2227.1991.tb11873.x.
In 19 non-jaundiced and 22 jaundiced neonates, the serum albumin and bilirubin concentrations were measured during the first week of life. Some of the neonates were followed longitudinally. The albumin binding properties were evaluated by determining the reserve albumin concentration for monoacetyldiaminodiphenyl sulphone (MADDS), a deputy ligand for bilirubin. The reserve albumin concentration for MADDS increased with postnatal age. The reason for this increase is still unexplained. There was an inverse relation between the bilirubin and the reserve albumin concentrations, but when the bilirubin concentration increased by 1 mumol/l, the reserve albumin concentration for MADDS decreased by only 0.2 mumol/l. This shows that the reserve albumin concentration for MADDS does not give a direct measure of the bilirubin binding ability of the serum albumin molecule. In spite of this, it is still possible that a low reserve albumin concentration for MADDS is a risk factor for bilirubin encephalopathy.
在19名非黄疸新生儿和22名黄疸新生儿中，于出生后第一周测量了血清白蛋白和胆红素浓度。部分新生儿进行了纵向随访。通过测定胆红素的替代配体单乙酰二氨基二苯砜（MADDS）的储备白蛋白浓度来评估白蛋白结合特性。MADDS的储备白蛋白浓度随出生后年龄增加。这种增加的原因仍未明确。胆红素与储备白蛋白浓度之间呈负相关，但当胆红素浓度每增加1μmol/L时，MADDS的储备白蛋白浓度仅降低0.2μmol/L。这表明MADDS的储备白蛋白浓度并不能直接衡量血清白蛋白分子的胆红素结合能力。尽管如此，MADDS储备白蛋白浓度低仍有可能是胆红素脑病的一个危险因素。
