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在丹麦部分地区,孕妇的尿碘排泄量低,血清甲状腺球蛋白水平高。

Urinary iodine excretion is low and serum thyroglobulin high in pregnant women in parts of Denmark.

作者信息

Pedersen K M, Börlum K G, Knudsen P R, Hansen E S, Johannesen P L, Laurberg P

机构信息

Medical Department M, Randers Central Sygehus, Denmark.

出版信息

Acta Obstet Gynecol Scand. 1988;67(5):413-6. doi: 10.3109/00016348809004251.

DOI:10.3109/00016348809004251
PMID:3218459
Abstract

In the Randers area of Denmark urinary iodine excretion (which reflects iodine intake) was found to be much lower than recommended intake levels, both in women in late pregnancy [52(23-118) micrograms iodine/g creatinine, median, range, n = 20] and in non-pregnant controls [42(23-71), n = 20]. Serum thyroglobulin which is high in iodine deficiency was 32.5 micrograms/l (median) (range 10.5-78.0) in the control women and considerably higher in the pregnant women [67.0 micrograms/l (9.0-385)]. This increase was probably due to the extra iodine requirement of pregnancy which was not satisfied with an adequate increase in iodine intake. The results may suggest that pregnant women in this area should receive iodine supplementation and that a general program of iodine supplementation should be considered.

摘要

在丹麦的兰讷斯地区,发现孕妇晚期女性(尿碘排泄量[反映碘摄入量]为52[23 - 118]微克碘/克肌酐,中位数,范围,n = 20)和非孕对照组(42[23 - 71],n = 20)的尿碘排泄量均远低于推荐摄入量水平。在碘缺乏时升高的血清甲状腺球蛋白,在对照组女性中为32.5微克/升(中位数)(范围10.5 - 78.0),而在孕妇中则显著更高[67.0微克/升(9.0 - 385)]。这种升高可能是由于孕期额外的碘需求未因碘摄入量充分增加而得到满足。结果可能表明该地区的孕妇应补充碘,并且应考虑实施一项普遍的碘补充计划。

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引用本文的文献

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Eur Thyroid J. 2024 May 20;13(3). doi: 10.1530/ETJ-23-0230. Print 2024 Jun 1.
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Medicine (Baltimore). 2016 Nov;95(48):e5273. doi: 10.1097/MD.0000000000005273.
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Serum Thyroglobulin Concentration Is a Weak Marker of Iodine Status in a Pregnant Population with Iodine Deficiency.
血清甲状腺球蛋白浓度是碘缺乏孕妇群体碘状态的一个弱标志物。
Eur Thyroid J. 2016 Jul;5(2):120-4. doi: 10.1159/000446070. Epub 2016 May 20.
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Iodine status in the Nordic countries - past and present.北欧国家的碘状况——过去与现在。
Food Nutr Res. 2016 Jun 8;60:31969. doi: 10.3402/fnr.v60.31969. eCollection 2016.
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Challenges in the evaluation of urinary iodine status in pregnancy: the importance of iodine supplement intake and time of sampling.妊娠尿碘评估的挑战:碘补充摄入和采样时间的重要性。
Eur Thyroid J. 2014 Sep;3(3):179-88. doi: 10.1159/000365145. Epub 2014 Aug 29.
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Thyroid. 2014 Aug;24(8):1195-209. doi: 10.1089/thy.2014.0052. Epub 2014 Jun 12.
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