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血清血小板衍生生长因子在肺癌患者中显著降低，且在铂类化疗后持续下降。

Serum Platelet-Derived Growth Factor Is Significantly Lower in Patients with Lung Cancer and Continued to Decrease After Platinum-Based Chemotherapy.

作者信息

Ma Rong, Yang Qing, Cao Shengya, Liu Siwen, Cao Haixia, Xu Heng, Wu Jianzhong, Feng Jifeng

机构信息

Research Center for Clinical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, People's Republic of China.

Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221000, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Mar 4;13:1883-1892. doi: 10.2147/OTT.S239252. eCollection 2020.

DOI:10.2147/OTT.S239252
PMID:32184623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7061435/
Abstract

OBJECTIVE

This study aimed to investigate the diagnosis and prediction of serum platelet-derived growth factor (PDGF) level in patients with lung cancer (LC).

METHODS

Serum concentrations of PDGF-AA and PDGF-AB/BB were determined via Luminex assay in 210 patients with non-small cell lung cancer (NSCLC), 33 patients with small cell lung cancer (SCLC), and 168 healthy controls.

RESULTS

The serum levels of PDGF-AA and PDGF-AB/BB were lower in patients with NSCLC ( < 0.05) and SCLC ( < 0.05), compared to healthy controls. The concentration of PDGF-AA or PDGF-AB/BB continued to markedly decrease in NSCLC after therapy with platinum-based chemotherapy ( < 0.05). The median survival times were 29 and 38 months in patients with NSCLC who received PDGF-AA < 30 ng/mL and PDGF-AA ≥ 30 ng/mL ( = 0.0078), and 26 and 38 months in patients with NSCLC who received PDGF-AB/BB < 42 ng/mL and PDGF-AB/BB ≥ 42 ng/mL ( = 0.0001), respectively. At the individual protein level, PDGF-AA and PDGF-AB/BB had better diagnostic values for NSCLC (AUC = 0.905, AUC = 0.922, respectively).

CONCLUSION

Serum PDGF may be a potential biomarker for diagnosis of patients with NSCLC and SCLC. However, the prognostic value of serum PDGF in patients with NSCLC harboring mutations and different therapies requires additional investigation.

摘要

目的

本研究旨在探讨肺癌（LC）患者血清血小板衍生生长因子（PDGF）水平的诊断及预测价值。

方法

采用Luminex检测法测定210例非小细胞肺癌（NSCLC）患者、33例小细胞肺癌（SCLC）患者及168例健康对照者血清中PDGF-AA和PDGF-AB/BB的浓度。

结果

与健康对照者相比，NSCLC患者和SCLC患者血清中PDGF-AA和PDGF-AB/BB水平较低（<0.05）。以铂类为基础的化疗治疗后，NSCLC患者血清中PDGF-AA或PDGF-AB/BB浓度持续显著降低（<0.05）。PDGF-AA<30 ng/mL和PDGF-AA≥30 ng/mL的NSCLC患者中位生存时间分别为29个月和38个月（P=0.0078）；PDGF-AB/BB<42 ng/mL和PDGF-AB/BB≥42 ng/mL的NSCLC患者中位生存时间分别为26个月和38个月（P=0.0001）。在个体蛋白水平上，PDGF-AA和PDGF-AB/BB对NSCLC具有较好的诊断价值（AUC分别为0.905和0.922）。

结论

血清PDGF可能是NSCLC和SCLC患者诊断的潜在生物标志物。然而，血清PDGF在携带突变的NSCLC患者及不同治疗中的预后价值需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/65efb55fab95/OTT-13-1883-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/a14d2a66f816/OTT-13-1883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/ccabd55fe43a/OTT-13-1883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/43248ca7bc64/OTT-13-1883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/36761af95b1b/OTT-13-1883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/65efb55fab95/OTT-13-1883-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/a14d2a66f816/OTT-13-1883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/ccabd55fe43a/OTT-13-1883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/43248ca7bc64/OTT-13-1883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/36761af95b1b/OTT-13-1883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df04/7061435/65efb55fab95/OTT-13-1883-g0005.jpg

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