Xu Yichi, Jiang Wenxiao, Xie Shangdan, Xue Fang, Zhu Xueqiong
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Cancer Manag Res. 2020 Mar 4;12:1601-1609. doi: 10.2147/CMAR.S244280. eCollection 2020.
Inhaled anesthetics are widely used for induction and maintenance of anesthesia during surgery, including isoflurane, sevoflurane, desflurane, haloflurane, nitrous oxide (NO), enflurane and xenon. Nowadays, it is controversial whether inhaled anesthetics may influence the tumor progression, which urges us to describe the roles of different inhaled anesthetics in human cancers. In the review, the relationships among the diverse inhaled anesthetics and patient outcomes, immune response and cancer cell biology were discussed. Moreover, the mechanisms of various inhaled anesthetics in the promotion or inhibition of carcinogenesis were also reviewed. In summary, we concluded that several inhaled anesthetics have different immune functions, clinical outcomes and cancer cell biology, which could contribute to opening new avenues for selecting suitable inhaled anesthetics in cancer surgery.
吸入麻醉剂广泛用于手术期间麻醉的诱导和维持，包括异氟烷、七氟烷、地氟烷、氟烷、氧化亚氮（NO）、恩氟烷和氙气。如今，吸入麻醉剂是否会影响肿瘤进展存在争议，这促使我们描述不同吸入麻醉剂在人类癌症中的作用。在这篇综述中，讨论了各种吸入麻醉剂与患者预后、免疫反应和癌细胞生物学之间的关系。此外，还综述了各种吸入麻醉剂促进或抑制致癌作用的机制。总之，我们得出结论，几种吸入麻醉剂具有不同的免疫功能、临床结果和癌细胞生物学特性，这可能有助于为癌症手术中选择合适的吸入麻醉剂开辟新途径。
