Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Eur J Epidemiol. 2020 Mar;35(3):283-293. doi: 10.1007/s10654-020-00621-8. Epub 2020 Mar 17.
Adherence to healthful dietary patterns is associated with lower body mass index (BMI) in adults; however, whether maternal diet quality during peripregnancy is related to a lower overweight risk in the offspring remains to be elucidated. We investigated the associations between the Alternate Healthy Eating Index (AHEI), Alternate Mediterranean Diet (aMED) and Dietary Approach to Stop Hypertension (DASH) during peripregnancy and offspring weight outcomes in a study including 2729 mother-child pairs from the Nurses' Health Study II and offspring cohort Growing Up Today Study II. Children, 12-14 years at baseline were 21-23 years at the last follow-up. Overweight or obesity was defined according to International Obesity Task Force (< 18 years) and World-Health-Organization guidelines (18 + years). Maternal dietary patterns were calculated from food frequency questionnaires. Log-binomial models were used to estimate relative risks (RR) and 95% confidence intervals. In models adjusted for sex, gestational age at delivery and maternal total energy intake, greater maternal adherence to aMED and DASH, but not AHEI, was associated with lower overweight risk in the offspring (RR = 0.82 [0.70-0.97] for aMED and 0.86 [0.72-1.04] for DASH, P for trend < 0.05 for both). After additional adjustment for maternal pre-pregnancy lifestyle factors and socio-demographic characteristic, none of the diet quality scores were significantly associated with offspring overweight risk. Maternal pre-pregnancy BMI did not modify any of these associations. In this population of generally well-nourished women, maternal healthful dietary patterns during the period surrounding pregnancy were not independently associated with offspring overweight risk at ages 12-23 years.
在成年人中，遵循健康的饮食模式与较低的体重指数（BMI）相关；然而，围孕期母体饮食质量是否与后代较低的超重风险相关仍有待阐明。我们研究了围孕期替代健康饮食指数（AHEI）、替代地中海饮食（aMED）和停止高血压的饮食方法（DASH）与护士健康研究 II 及其后代队列成长今天研究 II 中 2729 对母子对的后代体重结果之间的关系。在基线时，儿童为 12-14 岁，最后随访时为 21-23 岁。超重或肥胖根据国际肥胖工作组（<18 岁）和世界卫生组织（18 岁+）的指南定义。母体饮食模式由食物频率问卷计算得出。对数二项式模型用于估计相对风险（RR）和 95%置信区间。在调整了性别、分娩时的胎龄和母体总能量摄入的模型中，更大程度地遵循 aMED 和 DASH 饮食与后代较低的超重风险相关（aMED 的 RR=0.82 [0.70-0.97]，DASH 的 RR=0.86 [0.72-1.04]，P 趋势值均<0.05）。在进一步调整了母体孕前生活方式因素和社会人口特征后，这些饮食质量评分均与后代超重风险无显著相关性。母体孕前 BMI 没有改变这些关联中的任何一个。在这个营养状况普遍良好的女性人群中，围孕期健康的饮食模式与 12-23 岁后代的超重风险无关。
