Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
J Tradit Chin Med. 2019 Apr;39(2):213-220.
To study the meridian tropism (MT) for three Chinese medicines: Tinglizi (Semen Lepidii Apetali, TLZ), Yiyiren (Semen Coicis, YYR), Cheqianzi (Semen Plantaginis, CQZ) in vivo experiments.
The extracts of TLZ, YYR, CQZ were orally administered to rats at a dose 234, 700 and 350 mg/kg, respectively. The urinary excretion rate, loss in weight of rats and the electrolyte levels in the plasma were measured, in order to assess the mechanisms of the three traditional Chinese diuretic medicines.
TLZ, YYR and CQZ exhibited obvious diuretic effect and reduced the weight of saline-loaded animals. All the three diuretic medicines differentially reduced various serum, urinary, lung, stomach, kidney and hormonal markers, thus indicating the different mechanisms of action and a close resemblance with their different meridian as per the MT theory.
Our findings suggest that the three Traditional Chinese Medicine (TCM) medicines-TLZ, YYR and CQZ- possess different Shamisen meridian. This can support the regimen of treating the same disease with different therapies in TCM theory.
通过体内实验研究三种中药的经络归经特性：萹蓄（萹蓄，TLZ）、薏苡仁（薏苡仁，YYR）、车前子（车前子，CQZ）。
TLZ、YYR、CQZ 提取物分别以 234、700 和 350mg/kg 的剂量灌胃给药，测定尿排泄率、大鼠体重减轻和血浆电解质水平，以评估三种传统中药利尿药的作用机制。
TLZ、YYR 和 CQZ 均表现出明显的利尿作用，并减轻盐水负荷动物的体重。三种利尿药均不同程度地降低了各种血清、尿液、肺、胃、肾和激素标志物，表明其作用机制不同，与经络归经理论的不同经络密切相关。
我们的研究结果表明，三种中药 TLZ、YYR 和 CQZ 具有不同的 Shamisen 经络。这可以支持中医理论中用不同疗法治疗同一疾病的方案。
