Pan Li-Ping, Zhu Lanxin, Wang Bing-Xue, Li Yi-Qi, Gao Li, Zhao Hui Hui
Institute of Ethnic Medicine and Pharmacy, Beijing University of Chinese Medicine, Beijing, China.
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Front Med (Lausanne). 2025 Apr 7;12:1522163. doi: 10.3389/fmed.2025.1522163. eCollection 2025.
Traditional Chinese medicine has great advantages in improving symptoms of CHF such as chest tightness, shortness of breath, and fatigue. In addition, some traditional Chinese medicines can be used as both medicine and food, which have good effects on the prevention and treatment of CHF patients at home.
A comprehensive search across China National Knowledge Infrastructure (CNKI), Wanfang, and Wei Pu (VIP) databases was conducted to retrieve pre-2022 literature related to CHF. After standardization, frequency analysis and Apriori algorithm were used to analyze these data.
Among 626 effective medical records, Fuling, Huangqi, and Danshen are the most commonly used herbs; The medication for chest tightness is closely related to Tinglizi; The medication for palpitations is closely related to Guizhi, Fuzi, Zhigancao, and Wuweizi; The medication of fatigue and poor appetite is closely related to Huangqi and Baizhu; The medication for lower limb edema is closely related to Fuling and Tinglizi; The medication for coughing is closely related to the use of Tinglizi, Wuweizi, Kuxingren, and Sangbaipi; Insomnia is closely related to Suanzaoren and Dazao.
The components in traditional Chinese medicine that have anti heart failure effects and reliable evidence can be potential candidates for drug discovery, while dietary therapeutic herbs such as Fuling, Huangqi, Danshen, and Zhigancao can be developed as health products.
中医在改善慢性心力衰竭（CHF）的胸闷、气短、乏力等症状方面具有很大优势。此外，一些中药药食同源，对CHF患者居家防治有良好效果。
全面检索中国知网（CNKI）、万方和维普（VIP）数据库，以获取2022年前与CHF相关的文献。标准化处理后，采用频数分析和Apriori算法对这些数据进行分析。
626份有效病历中，茯苓、黄芪、丹参是最常用的药物；胸闷用药与葶苈子密切相关；心悸用药与桂枝、附子、炙甘草、五味子密切相关；乏力、食欲不振用药与黄芪、白术密切相关；下肢水肿用药与茯苓、葶苈子密切相关；咳嗽用药与葶苈子、五味子、苦杏仁、桑白皮的使用密切相关；失眠与酸枣仁、大枣密切相关。
具有抗心力衰竭作用且证据可靠的中药成分可作为药物研发的潜在候选物，而茯苓、黄芪、丹参、炙甘草等食疗中药可开发为保健品。
