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归脾经的中药可调节酵母诱导发热大鼠的体温。

The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats.

机构信息

Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

出版信息

Phytomedicine. 2020 Aug;74:152815. doi: 10.1016/j.phymed.2018.12.038. Epub 2018 Dec 31.

DOI:10.1016/j.phymed.2018.12.038
PMID:30833146
Abstract

BACKGROUND

According to traditional Chinese medicine (TCM) theory, the herbal property is the most important guiding principle of ancient medication in China. The classification of warm- and cold-stimulating TCM is defined mainly based on the effects of herbs in regulating body temperature; however, the underlying mechanism of such distinction has not been fully identified.

METHODS

Here, four commonly used spleen-meridian herbs, Ginseng Radix and Astragali Radix as typical warm-stimulating herbs, and Nelumbinis Semen and Coicis Semen as typical cold-stimulating herbs, were selected to test their effects in regulating body temperature, as well as its triggered thermo-regulatory factors and energy related metabolites, in yeast-induced fever rats.

RESULTS

The intake of Astragali Radix increased body temperature in yeast-induced fever rats; while Coicis Semen showed cooling effects in such rats. In parallel, the levels of cAMP, PGE and thermo-related metabolites, including choline, creatine, alanine, lactate and leucine, in the blood of yeast-induced rats were increased significantly by the intake of Astragali Radix. Oppositely, the cold-stimulating herbs, Nelumbinis Semen and Coicis Semen, showed cooling effects by increasing certain metabolites, e.g. histidine, tyrosine, lipid, myo-inositol, as well as AVP level.

CONCLUSION

Here, we compared different effects of warm and cooling spleen-meridian herbs in the regulation of body temperature. By providing an intuitive comparison of thermo-regulatory factors and related metabolites after intake of selected herbs, the mechanism behind the warm and cooling effects of specific herbs were revealed.

摘要

背景

根据中医理论,草药的药性是中国古代用药的最重要指导原则。温凉性中药的分类主要是基于草药调节体温的作用来定义的;然而,这种区别的潜在机制尚未完全确定。

方法

在这里,选择四种常用的脾经草药,人参和黄芪作为典型的温性刺激草药,以及莲子和薏苡仁作为典型的凉性刺激草药,测试它们在调节体温方面的作用,以及其触发的体温调节因子和与能量相关的代谢物,在酵母诱导发热大鼠中。

结果

黄芪的摄入使酵母诱导发热大鼠的体温升高;而薏苡仁在这种大鼠中表现出降温作用。与此同时,在酵母诱导的大鼠血液中,cAMP、PGE 和与体温相关的代谢物,包括胆碱、肌酸、丙氨酸、乳酸和亮氨酸的水平,因摄入黄芪而显著升高。相反,凉性脾经草药,莲子和薏苡仁,通过增加某些代谢物,如组氨酸、酪氨酸、脂质、肌醇和 AVP 水平,表现出降温作用。

结论

在这里,我们比较了温凉脾经草药在调节体温方面的不同作用。通过直观比较摄入选定草药后体温调节因子和相关代谢物的变化,揭示了特定草药的温凉作用的机制。

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