Hsieh M T, Chen H C, Kao H C, Shibuya T
Proc Natl Sci Counc Repub China B. 1986 Oct;10(4):263-8.
Previously, we found that the ancient Chinese remedy of Suanzaorentang was a promising anxiolytic drug (Chen and Hsieh, 1985; Chen and Hsieh, 1985a). We also found that Suanzaorentang decreased the turnover rate of central monoamines and central catecholaminergic activity (Hsieh, et al., 1986). In this study, we found that 5-hydroxytryptophan (5-HTP) induced decrease in locomotor activity was significantly antagonized by Suanzaorentang, p-chlorophenylalanine (p-CPA) induced increase in locomotor activity was significantly inhibited by Suanzaorentang, Suanzaorentang had no significant effects on baclofen, muscimol, aminooxyacetic acid (AOAA) and thiosemicarbazide induced changes in locomotor activity, Suanzaorentang significantly decreased vanillylmandelic acid (VMA) in striatum and hippocampus, homovanillic acid (HVA) in hippocampus and 5-hydroxyindol acetic acid (5-HIAA) in striatum and hypothalamus, Suanzaorentang significantly reversed the alpha-methyltyrosine (alpha-MT) produced decrease in DA concentrations in striatum and hippocampus, and (6) Suanzaorentang significantly reversed the p-CPA produced decrease in 5-HT concentrations on amygdala. These facts implied that Suanzaorentang might decrease the serotonergic activity but have no significant effect on GABAergic activity. The main locus of action might be in the limbic system.
此前，我们发现中国古代方剂酸枣仁汤是一种很有前景的抗焦虑药物（Chen和Hsieh，1985；Chen和Hsieh，1985a）。我们还发现酸枣仁汤可降低中枢单胺的周转率和中枢儿茶酚胺能活性（Hsieh等人，1986）。在本研究中，我们发现酸枣仁汤可显著拮抗5-羟色氨酸（5-HTP）诱导的运动活性降低，显著抑制对氯苯丙氨酸（p-CPA）诱导的运动活性增加，酸枣仁汤对巴氯芬、蝇蕈醇、氨氧基乙酸（AOAA）和氨基硫脲诱导的运动活性变化无显著影响，酸枣仁汤可显著降低纹状体和海马中的香草扁桃酸（VMA）、海马中的高香草酸（HVA）以及纹状体和下丘脑中的5-羟吲哚乙酸（5-HIAA），酸枣仁汤可显著逆转α-甲基酪氨酸（α-MT）导致的纹状体和海马中多巴胺浓度降低，并且（6）酸枣仁汤可显著逆转p-CPA导致的杏仁核中5-羟色胺浓度降低。这些事实表明酸枣仁汤可能降低血清素能活性，但对γ-氨基丁酸能活性无显著影响。其主要作用部位可能在边缘系统。
