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台湾地区唑类耐药烟曲霉临床分离株的多中心研究。

Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan.

出版信息

Emerg Infect Dis. 2020 Apr;26(4):804-806. doi: 10.3201/eid2604.190840.

DOI:10.3201/eid2604.190840
PMID:32186508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7101115/
Abstract

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR/L98H, TR/L98H/S297T/F495I, and TR/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

摘要

在一项多中心研究中，我们确定了台湾地区烟曲霉唑类耐药的流行率为 4%。耐药性主要来自环境（TR/L98H、TR/L98H/S297T/F495I 和 TR/Y121F/T289A 突变），但偶尔也会在唑类药物治疗期间出现。对于唑类耐药的曲霉病，我们观察到了高死亡率，这需要在医疗保健中进行诊断管理，以及在环境中进行抗真菌药物管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d4/7101115/50155a82b9af/19-0840-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d4/7101115/50155a82b9af/19-0840-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d4/7101115/50155a82b9af/19-0840-F.jpg

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