2015 年至 2017 年美国通过被动监测对唑类耐药烟曲霉中 TR/L98H 突变的检测。
Detection of TR/L98H Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017.
机构信息
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
出版信息
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.02240-17. Print 2018 May.
Abstract
The emergence of azole-resistant has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein Cyp51Ap contribute to this resistance, with the most concerning being the environmentally derived TR/L98H and TR/Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of the population in the United States for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution, and five of those isolates harbored the TR/L98H mutation.
摘要
唑类耐药的出现已成为世界许多地区的临床问题。唑类靶蛋白 Cyp51Ap 中的几个氨基酸突变导致了这种耐药性，其中最令人关注的是环境衍生的 TR/L98H 和 TR/Y121F/T289A 突变。在这里，我们进行了被动监测，以评估美国的一个 群体样本中这些突变的存在情况。我们发现通过肉汤微量稀释法，有 1.4%的分离株表现出升高的 MIC，其中 5 株分离株携带 TR/L98H 突变。
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