Radice M, Albertini A, Alli C, Canciani C, Di Tullio M, Manzini M, Mariotti G, Salmoirago E, Taioli E, Zatta G
Semeiotica Medica, Università di Milano, Italy.
Am J Med. 1988 Mar 11;84(3A):133-5. doi: 10.1016/0002-9343(88)90219-7.
Diastolic function of the left ventricle was assessed in 29 untreated patients with mild to moderate hypertension and in 21 normotensive control subjects using gated radionuclide ventriculography. In hypertensive patients, the time to peak filling rate was significantly longer (p less than 0.01) than that in control subjects, and first-third filling fraction and peak filling rate were significantly reduced (p less than 0.001). The ejection fraction and peak ejection rate were also significantly reduced in hypertensive patients (p less than 0.001). No relation was observed between diastolic functional impairment and age, cardiac hypertrophy, or severity of hypertension. Thus, early impairment of ventricular filling is present in hypertension, even in young patients without evidence of cardiac hypertrophy.
采用门控放射性核素心室造影术，对29例未经治疗的轻至中度高血压患者及21名血压正常的对照者的左心室舒张功能进行了评估。高血压患者的充盈峰值时间显著长于对照组（p<0.01），且前三分之一充盈分数和充盈峰值速率显著降低（p<0.001）。高血压患者的射血分数和射血峰值速率也显著降低（p<0.001）。未观察到舒张功能损害与年龄、心脏肥大或高血压严重程度之间存在关联。因此，高血压患者即使是无心脏肥大证据的年轻患者，也存在早期心室充盈受损的情况。
