Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
LTTA, University of Ferrara, Ferrara, Italy.
Mol Cancer. 2020 Mar 18;19(1):61. doi: 10.1186/s12943-020-01181-x.
Non-coding RNAs are now recognized as fundamental components of the cellular processes. Non-coding RNAs are composed of different classes, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Their detailed roles in breast cancer are still under scrutiny.
We systematically reviewed from recent literature the many functional and physical interactions of non-coding RNAs in breast cancer. We used a data driven approach to establish the network of direct, and indirect, interactions. Human curation was essential to de-convolute and critically assess the experimental approaches in the reviewed articles. To enrol the scientific papers in our article cohort, due to the short time span (shorter than 5 years) we considered the journal impact factor rather than the citation number. The outcome of our work is the formal establishment of different sub-networks composed by non-coding RNAs and coding genes with validated relations in human breast cancer. This review describes in a concise and unbiased fashion the core of our current knowledge on the role of lncRNAs, miRNAs and other non-coding RNAs in breast cancer.
A number of coding/non-coding gene interactions have been investigated in breast cancer during recent years and their full extent is still being established. Here, we have unveiled some of the most important networks embracing those interactions, and described their involvement in cancer development and in its malignant progression.
非编码 RNA 现在被认为是细胞过程的基本组成部分。非编码 RNA 由不同的类别组成，包括 microRNAs (miRNAs) 和长非编码 RNA (lncRNAs)。它们在乳腺癌中的详细作用仍在研究中。
我们从最近的文献中系统地综述了非编码 RNA 在乳腺癌中的许多功能和物理相互作用。我们使用数据驱动的方法来建立直接和间接相互作用的网络。对综述文章中的实验方法进行去卷积和严格评估，人类策展至关重要。为了将科学论文纳入我们的文章队列，由于时间跨度较短（短于 5 年），我们考虑了期刊影响因子而不是引用数量。我们工作的结果是正式建立了不同的子网络，这些子网络由非编码 RNA 和编码基因组成，在人类乳腺癌中有经过验证的关系。本综述以简洁、无偏见的方式描述了我们目前对 lncRNA、miRNA 和其他非编码 RNA 在乳腺癌中作用的核心认识。
近年来，已经研究了许多编码/非编码基因相互作用在乳腺癌中的作用，其全部范围仍在建立之中。在这里，我们揭示了一些最重要的网络，包括这些相互作用，并描述了它们在癌症发展及其恶性进展中的参与。
