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COVID-19:已知、未知和问题。

COVID-19: Knowns, Unknowns, and Questions.

机构信息

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

出版信息

mSphere. 2020 Mar 18;5(2):e00203-20. doi: 10.1128/mSphere.00203-20.

DOI:10.1128/mSphere.00203-20
PMID:32188753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7082143/
Abstract

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.

摘要

2019 年末,中国湖北省出现了严重急性呼吸综合征冠状病毒 2(SARS-CoV-2),这表明冠状病毒具有引发疫情的潜力。该病毒在短短 2 个月内迅速传播到世界各地,这突显了此类病毒的传染性以及它们可能导致的高发病率和死亡率。我们在回答有关 SARS-CoV-2 目前爆发的问题的同时,强调了冠状病毒生物学的现有知识状况。

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China CDC Wkly. 2020 Feb 21;2(8):123-124.
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Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.突破:磷酸氯喹在临床研究中显示出对 COVID-19 相关肺炎的明显疗效。
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The reproductive number of COVID-19 is higher compared to SARS coronavirus.与严重急性呼吸综合征冠状病毒相比,新型冠状病毒肺炎的繁殖数更高。
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒(2019 - 新冠病毒)。
Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4.
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Viruses. 2020 Jan 24;12(2):135. doi: 10.3390/v12020135.
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