Postgraduate Dentistry Program, Federal University of Maranhão, São Luís, Brazil.
Dentistry, Federal University of Maranhão, São Luís, Brazil.
J Clin Periodontol. 2020 Jun;47(6):668-675. doi: 10.1111/jcpe.13284. Epub 2020 Apr 20.
To investigate the association among iron overload, periodontal status, and periodontitis progression rate in sickle cell anaemia (SCA).
This case series evaluated 123 patients. Clinical attachment level (CAL) and probing depth (PD) were evaluated at six sites per tooth. Alveolar bone loss was estimated using periapical radiography. Study outcomes were periodontal status (measured as number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm) and periodontitis progression rate (determined as ratio of alveolar bone loss to age). Serum transferrin saturation and ferritin levels were obtained from medical records. Poisson regression was performed to estimate associations. Covariables included in the adjusted models (comorbidities, skin colour, socioeconomic class, and vaso-occlusive crisis) were defined by DAGs.
Serum transferrin saturation level revealed a significant positive association with the number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm. Patients with serum transferrin saturation level of >45% were 1.93 times more likely to have rapid periodontitis progression.
High serum transferrin saturation level is associated with a greater extent of periodontitis and rapid periodontitis progression in SCA.
探讨铁过载、牙周状况与镰状细胞贫血（SCA）中牙周炎进展率之间的关系。
本病例系列评估了 123 名患者。每颗牙的六个位点评估临床附着水平（CAL）和探诊深度（PD）。使用根尖片评估牙槽骨丧失。研究结果为牙周状况（以 CAL≥3mm、CAL≥5mm、PD≥4mm 和 PD≥6mm 的位点数量来衡量）和牙周炎进展率（通过牙槽骨丧失与年龄的比值来确定）。从病历中获得血清转铁蛋白饱和度和铁蛋白水平。采用泊松回归估计关联。调整模型中的协变量（合并症、肤色、社会经济阶层和血管阻塞性危象）由 DAG 定义。
血清转铁蛋白饱和度与 CAL≥3mm、CAL≥5mm、PD≥4mm 和 PD≥6mm 的位点数量呈显著正相关。血清转铁蛋白饱和度水平>45%的患者发生快速牙周炎进展的可能性是前者的 1.93 倍。
高血清转铁蛋白饱和度与 SCA 中更严重的牙周炎和快速牙周炎进展有关。
