Medical Center of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
School of Stomatology, Jinan University, Guangzhou 510630, China.
Cells. 2022 Oct 24;11(21):3349. doi: 10.3390/cells11213349.
Periodontitis is a chronic inflammatory disease associated with bacterial biofilm. It is characterized by loss of periodontal support tissue and has long been considered as a "silent disease". Because it is difficult to prevent and has a health impact that can not be ignored, researchers have been focusing on a mechanism-based treatment model. Ferroptosis is an iron-dependent regulatory form of cell death, that directly or indirectly affects glutathione peroxidase through different signaling pathways, resulting in a decrease in cell antioxidant capacity, accumulation of reactive oxygen species and lipid peroxidation, which cause oxidative cell death and tissue damage. Recently, some studies have proven that iron overload, oxidative stress, and lipid peroxidation exist in the process of periodontitis. Based on this, this article reviews the relationship between periodontitis and ferroptosis, in order to provide a theoretical reference for future research on the prevention and treatment of periodontal disease.
牙周炎是一种与细菌生物膜相关的慢性炎症性疾病。它的特征是牙周支持组织丧失，长期以来一直被认为是一种“沉默的疾病”。由于难以预防且对健康的影响不可忽视，研究人员一直专注于基于机制的治疗模型。铁死亡是一种铁依赖性的细胞死亡调节形式，它通过不同的信号通路直接或间接地影响谷胱甘肽过氧化物酶，导致细胞抗氧化能力下降，活性氧和脂质过氧化产物积累，从而引起氧化细胞死亡和组织损伤。最近，一些研究已经证明在牙周炎的发生发展过程中存在铁过载、氧化应激和脂质过氧化。基于这一点，本文综述了牙周炎与铁死亡之间的关系，以期为牙周病防治的未来研究提供理论参考。
