Graduate Dentistry Program, Federal University of Maranhão, São Luís, Maranhão, Brazil.
Department of Public Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
J Clin Periodontol. 2022 Mar;49(3):221-229. doi: 10.1111/jcpe.13580. Epub 2021 Dec 21.
To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in post-menopausal (PM) women.
Data from 982 PM women participating in NHANES III were analysed. Exposures were high ferritin (≥300 μg/ml) and transferrin saturation (≥45%). The primary outcome was moderate/severe periodontitis defined according to Centers for Disease Control and Prevention and the American Academy of Periodontology. The extent of periodontitis was also assessed as outcome: proportion of sites affected by clinical attachment loss ≥4 mm and probing depth ≥4 mm. Crude and adjusted prevalence ratio (PR) and mean ratio (MR) were estimated using Poisson regression.
The prevalence of moderate/severe periodontitis was 27.56%. High ferritin was associated with moderate/severe periodontitis in the crude (PR 1.55, p = .018) and in the final adjusted model (PR 1.53, p = .008). High ferritin and transferrin saturation levels were associated with a higher proportion of sites with clinical attachment loss ≥4 mm (p < .05).
The increasing serum iron markers seem to contribute to periodontitis severity and extent in PM women.
研究绝经后女性（PM）血清铁标志物（铁蛋白和转铁蛋白饱和度）升高与牙周炎严重程度和范围的关系。
分析了参与 NHANES III 的 982 名 PM 女性的数据。暴露因素为高铁蛋白（≥300μg/ml）和转铁蛋白饱和度（≥45%）。主要结局为根据疾病控制与预防中心和美国牙周病学会定义的中重度牙周炎。牙周炎的严重程度也作为结局进行评估：≥4mm 临床附着丧失和≥4mm 探诊深度影响的位点比例。使用泊松回归估计粗患病率比（PR）和平均患病率比（MR）。
中重度牙周炎的患病率为 27.56%。铁蛋白升高与未经调整（PR 1.55，p=0.018）和最终调整模型（PR 1.53，p=0.008）中的中重度牙周炎相关。高铁蛋白和转铁蛋白饱和度与≥4mm 临床附着丧失的位点比例较高相关（p<0.05）。
血清铁标志物的升高似乎与 PM 女性的牙周炎严重程度和范围有关。
