Gol'dberg E D, Novitskiĭ V V, Fursov S E
Antibiot Khimioter. 1988 Sep;33(9):671-6.
The morphological and functional states of hemopoiesis at late periods (up to 6 months) after using daunorubicin, carminomycin and doxorubicin, antitumor antibiotics of the anthracycline group in doses of 1/10 LD50 for 10 days were studied on 764 noninbred rats and 240 BALB/c mice. On various compensatory-functional models of hemopoiesis strain there was shown persisting inhibition of hematopoietic tissue functional activity and limited reserve reactions of granulocyto- and erythropoiesis 3 and to a lesser extent 6 months after the cytostatic action.
在764只非近交系大鼠和240只BALB/c小鼠身上，研究了使用柔红霉素、卡米诺霉素和阿霉素（蒽环类抗肿瘤抗生素，剂量为1/10 LD50，持续10天）后晚期（长达6个月）造血的形态和功能状态。在各种造血系的代偿功能模型上，显示出在细胞抑制作用后3个月，造血组织功能活动持续受到抑制，粒细胞生成和红细胞生成的储备反应有限，6个月时这种抑制程度较轻。
