[Reactivity of the blood system in the late periods following administration of the antitumor antibiotic rubomycin].

The reserve potentialities of granulocyto- and erythropoesis were studied in noninbred rats and BALB/c mice using morphological functional methods and various compensatory-functional simulators of hemopoiesis strain 1.3 and 6 months after treatment with rubomycin at a therapeutic dose of 1.5 mg/kg. The animals were found to retain limited granulocyto- and erythropoesis compensatory reactions to additional hemopoesis-disturbing influences in spite of complete recovery of hematopoetic stem-cell pool, bone marrow and peripheral blood cell composition at remote terms after treatment.