吸入情况下咪普立定过敏潜能的实验研究
Experimental study of imiprotrin allergic potency in case of inhalation.
作者信息
Hrushka Oksana, Turkina Vira, Alyokhina Tatiana, Pryzyhley Hana, Kuzminov Borys
机构信息
Сentral research laboratory and laboratory of industrial toxicology , Danylo Halytsky Lviv National Medical University, Ukraine.
Department of hygiene and prophylactic toxicology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
出版信息
Interdiscip Toxicol. 2019 Sep;12(1):36-40. doi: 10.2478/intox-2019-0005. Epub 2020 Feb 20.
Probable changes were studied in rats' immune status under experimental conditions with inhalation route of type I pyrethroid- imiprotrin administration, which is the main component of a number of household insecticidal agents. The drug at a concentration of 45.0 mg/m interrupts immunological homeostasis in experimental animals. Nonspecific cellular component parameters of immune system have changed significantly. Imiprotrin is capable of inducing delayed hypersensitivity. Imiprotrin induces sensibilization under experimental conditions in more than half of the experimental animals, but the magnitude of the reactions to the intradermal administration of the drug has no probable differences, which allows imiprotin to be attributed to substances with moderate sensibilization potential.
在实验条件下，通过吸入途径给予大鼠Ⅰ型拟除虫菊酯-炔咪菊酯（多种家用杀虫剂的主要成分），研究其对大鼠免疫状态可能产生的变化。浓度为45.0毫克/立方米的该药物会破坏实验动物的免疫稳态。免疫系统的非特异性细胞成分参数发生了显著变化。炔咪菊酯能够诱导迟发型超敏反应。在实验条件下，超过半数的实验动物对炔咪菊酯产生了致敏作用，但对该药物皮内注射反应的程度没有明显差异，这使得炔咪菊酯可被归类为具有中等致敏潜力的物质。
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