Coil David A, Jospin Guillaume, Eisen Jonathan A
Genome Center, University of California, Davis, CA, United States.
Department of Evolution and Ecology, University of California, Davis, CA, United States.
J Genomics. 2020 Feb 21;8:25-29. doi: 10.7150/jgen.43162. eCollection 2020.
was first formally described in 2012 as a member of a novel species, genus, and proposed family of Christensenellaceae. was later shown in one study to be part of the most heritable taxonomic group in the human gut microbiome and to be enriched in people with low body mass index (BMI). Mouse work demonstrated that injection of cultured into germ-free mice prevented the onset of obesity after a fecal transplant to the mice from high BMI individuals. Here we describe the genome sequence of DSM 22607. Examination and analysis of the annotation revealed an unusually high number of genes predicted to be involved in carbohydrate metabolism, many of which were multiple homologs of RbsA, RbsB and RbsC, which together make up the Ribose ABC Transport System. These genes may be also involved in quorum sensing which could potentially relate to the importance of in the gut microbiome.
2012年，它首次被正式描述为一个新物种、新属以及拟议的克里斯滕森菌科家族的成员。后来在一项研究中表明，它是人类肠道微生物群中遗传性最强的分类群的一部分，并且在体重指数（BMI）较低的人群中富集。小鼠实验表明，将培养的[具体名称未给出]注射到无菌小鼠体内，在将粪便从高BMI个体移植到这些小鼠后，可预防肥胖的发生。在这里，我们描述了[具体名称未给出]DSM 22607的基因组序列。对注释的检查和分析揭示了预计参与碳水化合物代谢的基因数量异常之多，其中许多是RbsA、RbsB和RbsC的多个同源物，它们共同构成了核糖ABC转运系统。这些基因可能也参与群体感应，这可能与[具体名称未给出]在肠道微生物群中的重要性有关。
