Baharvand Parastoo, Hormozi Maryam, Aaliehpour Asghar
Department of Social Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Gastroenterol Hepatol Bed Bench. 2020 Winter;13(1):44-49.
This study aimed to investigate the prevalence of thyroid disease (TD) in untreated CD patients and to evaluate the effect of gender and age on its prevalence.
Celiac disease (CD) is a form of intestinal malabsorption syndrome which is closely related to endocrine disorders, especially autoimmune thyroid disease and diabetes The prevalence of TD is possibly high among patients with CD which necessitates the need for screening for TD among them.
This comparative cross-sectional study was conducted on 288 consecutive untreated patients with CD (mean age, 27.9±14) and 250 controls (mean age, 29.01±13.15) referred for endoscopy in a hospital located in Iran. Thyroid function was evaluated by measuring T3, T4, and TSH levels using ELISA technique, and testing anti-thyroperoxidase (anti-TPO) antibodies through electrochemiluminescence method. Data analysis was conducted in SPSS v.22 software using descriptive statistics and chi-squared test.
Thyroid disease prevalence was 4-fold higher in patients than in controls (13.6% vs. 3.2%, p<0.05). Hypothyroidism was diagnosed in 30 patients and 7 controls, while hyperthyroidism was observed in 9 patients and in one control. Chi-squared test results reported a significant difference in TD prevalence between patients and controls based on gender and age (p<0.05). In both groups, women were significantly more affected than men, and the TD prevalence was higher in younger patients compared to adults.
There was a strong association between thyroid dysfunction and CD. In this regard, it is necessary to screen patients for TD.
本研究旨在调查未经治疗的乳糜泻（CD）患者中甲状腺疾病（TD）的患病率，并评估性别和年龄对其患病率的影响。
乳糜泻（CD）是一种肠道吸收不良综合征，与内分泌紊乱密切相关，尤其是自身免疫性甲状腺疾病和糖尿病。CD患者中TD的患病率可能较高，因此有必要对他们进行TD筛查。
本比较性横断面研究对伊朗一家医院连续收治的288例未经治疗的CD患者（平均年龄27.9±14岁）和250例对照者（平均年龄29.01±13.15岁）进行了内镜检查。采用酶联免疫吸附测定（ELISA）技术测量T3、T4和促甲状腺激素（TSH）水平，并通过电化学发光法检测抗甲状腺过氧化物酶（抗TPO）抗体，以评估甲状腺功能。使用描述性统计和卡方检验在SPSS v.22软件中进行数据分析。
患者的甲状腺疾病患病率比对照者高4倍（13.6%对3.2%，p<0.05）。30例患者和7例对照者被诊断为甲状腺功能减退，9例患者和1例对照者被观察到甲状腺功能亢进。卡方检验结果显示，基于性别和年龄，患者与对照者之间的TD患病率存在显著差异（p<0.05）。在两组中，女性受影响的程度明显高于男性，与成年人相比，年轻患者的TD患病率更高。
甲状腺功能障碍与CD之间存在密切关联。在这方面，有必要对患者进行TD筛查。
