Aljanabi Nawar Muneer, Mamtani Sahil, Al-Ghuraibawi Muthanna Mohammed Hasan, Yadav Sunita, Nasr Lubna
Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Infectious Diseases Research, Veterans Affairs Medical Center, Lebanon, USA.
Cureus. 2020 Feb 5;12(2):e6885. doi: 10.7759/cureus.6885.
In this project, we are trying to review the articles that discuss the relationship between insulin signaling and Alzheimer's disease (AD). Another focus of this project is to find the best treatment regimen that can reduce the progression of AD in patients with impaired glucose metabolism. We used Pubmed database to collect our data and used the following keywords: Alzheimer's disease, insulin signaling pathway, type 3 diabetes, type 2 diabetes, insulin, and insulin resistance in our revision; we included free articles that were published in the last 10 years and excluded articles that were written in any language other than English. We reviewed 68 articles. Forty-nine out of 68 articles were containing materials that are relevant for this project. We found that there is a relation between AD and the insulin signaling pathway. Insulin signaling pathway impairment leads to hyperphosphorylation of Tau protein, which plays a vital role in AD pathology. The effect of insulin on cognition is bidirectional; the intranasal route of insulin showed to have a promising effect on cognition improvement. Subcutaneous and intravenous insulin can increase the risk of dementia. Further studies are encouraged to use a specific anti-diabetic medication that can reduce the progression of AD.
在本项目中，我们试图回顾那些探讨胰岛素信号传导与阿尔茨海默病（AD）之间关系的文章。本项目的另一个重点是找到最佳治疗方案，以减缓葡萄糖代谢受损患者的AD病情进展。我们使用PubMed数据库收集数据，并在文献综述中使用了以下关键词：阿尔茨海默病、胰岛素信号通路、3型糖尿病、2型糖尿病、胰岛素和胰岛素抵抗；我们纳入了过去10年发表的免费文章，并排除了非英文撰写的文章。我们回顾了68篇文章。68篇文章中有49篇包含与本项目相关的内容。我们发现AD与胰岛素信号通路之间存在关联。胰岛素信号通路受损会导致Tau蛋白过度磷酸化，而Tau蛋白在AD病理过程中起着至关重要的作用。胰岛素对认知的影响是双向的；鼻内注射胰岛素对改善认知显示出有前景的效果。皮下和静脉注射胰岛素会增加患痴呆症的风险。鼓励进一步研究使用能减缓AD病情进展的特定抗糖尿病药物。
