Karaca Onur, Ertaşkın Ayşegül
Anesthesiology and Reanimation, Aksaray University, Aksaray, TUR.
Anesthesiology and Reanimation, Aksaray University Training and Research Hospital, Aksaray, TUR.
Cureus. 2020 Feb 12;12(2):e6962. doi: 10.7759/cureus.6962.
Deliberate self-poisoning (DSP) is a common cause of intensive care hospitalization among young adults and a serious health problem worldwide. Demographic data vary according to geographical and sociocultural characteristics of the regions. In recent years, studies investigating epidemiological features and prognosis of these patients have increased. In our study, we retrospectively examined patients who committed suicide with drugs and were treated in the ICU of our hospital.
The files of 148 patients who took drugs or substances for committing suicide and who were hospitalized in the ICU of Aksaray Training and Research Hospital between 2015 and 2019 were examined. Demographic data of the patients, type of the agent used in the suicide, time to reach hospital, treatment methods applied, length of hospital stay, vital signs, complications, need for intubation, and mortality rates were recorded.
Mean age of the 148 patients who took drugs for suicide was 26.7. Female rate was 73%. The most frequently used drug for suicide was paracetamol (34.4%). Antidepressants took the second place and were followed by drugs in the NSAID group. The duration of admission in the hospital after taking the medicine ranged from 1 to 6 h, while it was less than 3 h in 68.2% of the patients. In most suicide patients, the treatment method was in the form of intravenous fluid and supportive therapy (95%). N-acetyl cysteine (paracetamol intoxication) was used in 7% of the patients, an intubation requirement developed in 2.7%, and three patients taking organophosphate died.
In studies conducted in developing countries such as Turkey, female sex (63%-71%) and 25 years of age have been found to be the proportion of the patients (56%-63%), whereas our study found even higher ratios compared to those (73%-66%). In studies conducted in developed countries, most commonly used agents for suicide were benzodiazepines and tricyclic antidepressants, while the most common suicide agent was paracetamol in our study. We believe that the reason for this could be the possibility of accessing the agent without a prescription.
蓄意自我中毒（DSP）是年轻成年人重症监护住院治疗的常见原因，也是全球范围内一个严重的健康问题。人口统计学数据因地区的地理和社会文化特征而异。近年来，针对这些患者的流行病学特征和预后的研究有所增加。在我们的研究中，我们回顾性地研究了在我院重症监护病房接受治疗的药物自杀患者。
对2015年至2019年间在阿克萨赖培训和研究医院重症监护病房住院的148例服用药物或物质自杀的患者档案进行了检查。记录了患者的人口统计学数据、自杀所用药物类型、到达医院的时间、应用的治疗方法、住院时间、生命体征、并发症、插管需求和死亡率。
148例药物自杀患者的平均年龄为26.7岁。女性比例为73%。最常被用于自杀的药物是对乙酰氨基酚（34.4%）。抗抑郁药位居第二，其次是非甾体抗炎药组的药物。服药后住院时间为1至6小时，68.2%的患者住院时间少于3小时。在大多数自杀患者中，治疗方法为静脉输液和支持治疗（95%）。7%的患者使用了N-乙酰半胱氨酸（用于对乙酰氨基酚中毒），2.7%的患者需要插管，3例服用有机磷的患者死亡。
在土耳其等发展中国家进行的研究中，发现女性（63%-71%）和25岁患者的比例分别为（56%-63%），而我们的研究发现这些比例甚至更高（73%-66%）。在发达国家进行的研究中，最常用于自杀的药物是苯二氮䓬类药物和三环类抗抑郁药，而在我们的研究中最常见的自杀药物是对乙酰氨基酚。我们认为造成这种情况可能是无需处方就能获取该药物的可能性。
