Aier Eye Hospital of Wuhan University, Wuhan, Hubei 430063, China.
Hankou Aier Eye Hospital, Wuhan, Hubei 430024, China.
Biomed Res Int. 2020 Feb 28;2020:7403842. doi: 10.1155/2020/7403842. eCollection 2020.
To evaluate the clinical and in vivo confocal microscopy outcome of lamellar keratoplasty combined with amniotic membrane transplantation for the treatment of corneal perforations.
In this retrospective, noncomparative, and interventional case series, 13 eyes of 13 patients with corneal perforation were included. All eyes were treated with lamellar keratoplasty combined with amniotic membrane transplantation for corneal reconstruction. Age, underlying etiology, location, size of corneal ulcer, size of corneal perforation, hospitalization days and follow-up time, and corneal confocal microscopy were investigated. Aqueous leakage, anterior chamber formation, epithelial healing time, and visual acuity (VA) were monitored after operation.
The cause of corneal perforation ( = 13) was classified as infectious ( = 13) was classified as infectious ( = 13) was classified as infectious (.
Lamellar keratoplasty combined with amniotic membrane transplantation may be an alternative, safe, and effective surgical therapy in the treatment of corneal perforations in the absence of a fresh donor cornea. We recommend this surgery to treat with the size of corneal perforation of <4 mm in diameter no matter peripheral or central corneal perforation, especially who had immune-related diseases.
评估板层角膜移植联合羊膜移植治疗角膜穿孔的临床和活体共聚焦显微镜结果。
在这项回顾性、非对照、干预性病例系列研究中，纳入了 13 例 13 只眼的角膜穿孔患者。所有患者均接受板层角膜移植联合羊膜移植进行角膜重建。研究人员调查了年龄、潜在病因、位置、角膜溃疡大小、角膜穿孔大小、住院天数和随访时间以及角膜共聚焦显微镜。术后监测房水漏、前房形成、上皮愈合时间和视力（VA）。
角膜穿孔的病因（ = 13）为感染性（ = 13）。
在没有新鲜供体角膜的情况下，板层角膜移植联合羊膜移植可能是治疗角膜穿孔的一种替代、安全且有效的手术治疗方法。我们建议对直径<4mm 的角膜穿孔进行手术治疗，无论穿孔位于周边还是中央角膜，特别是患有免疫相关性疾病的患者。
