Department of Anesthesiology, Tianjin Third Central Hospital, Nankai University Affinity the Third Central Hospital, The Third Central Clinical College of Tianjin Medical University, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China.
Aging (Albany NY). 2020 Mar 19;12(6):4907-4917. doi: 10.18632/aging.102918.
Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined terms for neurocognitive and biochemical changes with those for MCI and dementia. Data were extracted and checked by a second reviewer, systematically reviewed, and meta analyzed where appropriate. There was significant difference in favor of multicomponent exercise in cognition (WMD:0.18; 95%CI:0.02-0.34), attention (SMD=2.16; 95%CI:1.2to3.12) and executive function (SMD =0.80; 95%CI: 0.28to1.31), but not in memory. However, there was limited reporting of the effects of multicomponent exercise on depression and brain-derived neurotrophic factor for this group of people. In conclusion, this meta-analysis indicated that group exercises improve cognition, attention and executive function in community-dwelling older adults with mild cognitive impairment or Alzheimer's disease.
我们的目标是研究在社区中，轻度认知障碍或痴呆的老年人作为群体进行多成分运动锻炼是否对认知和脑源性神经营养因子有有益影响。通过 Emabase、Medline、PubMed 确定了八项研究。搜索词结合了神经认知和生化变化与 MCI 和痴呆的术语。由第二位审稿人提取和检查数据，进行系统审查，并在适当的情况下进行荟萃分析。多成分运动锻炼在认知（WMD：0.18；95%CI：0.02-0.34）、注意力（SMD=2.16；95%CI：1.2 到 3.12）和执行功能（SMD=0.80；95%CI：0.28 到 1.31）方面具有显著优势，但在记忆方面没有优势。然而，对于这组人群，关于多成分运动锻炼对抑郁和脑源性神经营养因子的影响的报告有限。总之，这项荟萃分析表明，群体运动锻炼可改善社区中轻度认知障碍或阿尔茨海默病老年人的认知、注意力和执行功能。
