1 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran.
2 Cellular & Molecular Research Center, Guilan University of Medical Science, Rasht, Iran.
Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):20-29. doi: 10.1177/1533317517727068. Epub 2017 Sep 25.
The effects of mental, physical, and combination of these two trainings were investigated on cognitive performance, serum level of brain derived neurotrophic factor (BDNF), and irisin in women diagnosed with mild cognitive impairment (MCI).
Forty-four participants were randomized into 4 groups: physical training (PH; 8 weeks' aerobic training, n = 11), mental training (ME; special computer gaming, n = 11), combined (PH + ME; n = 13), and control group (CO; n = 9).
Analysis of variance with Tukey post hoc test revealed a significant increase in working memory ( P = .012) and BDNF ( P = 0.024) in the ME compared with the CO group. Also the ME group in comparison with the PH group demonstrated better working memory ( P = .014) and processing speed ( P = .024).
Positive effect of mental training on the cognitive parameters, parallel with BDNF elevation, suggests that mental training is a more useful, safe, and persistent strategy to attenuate the progression of MCI probably via BDNF elevation, but the effect size is relatively small elevation.
本研究旨在探讨心理、生理和两者结合训练对认知表现、血清脑源性神经营养因子（BDNF）水平和鸢尾素的影响，研究对象为被诊断为轻度认知障碍（MCI）的女性。
44 名参与者被随机分为 4 组：体能训练组（PH；8 周有氧运动，n = 11）、心理训练组（ME；特殊电脑游戏，n = 11）、联合训练组（PH + ME；n = 13）和对照组（CO；n = 9）。
方差分析和 Tukey 事后检验显示，与 CO 组相比，ME 组的工作记忆（ P =.012）和 BDNF（ P = 0.024）显著增加。与 PH 组相比，ME 组的工作记忆（ P =.014）和处理速度（ P =.024）也更好。
心理训练对认知参数的积极影响，以及 BDNF 的升高，表明心理训练是一种更有用、更安全、更持久的策略，可以通过升高 BDNF 来减缓 MCI 的进展，但效果大小相对较小。
