Modeling tick vaccines: a key tool to improve protection efficacy.

: The development of more effective vaccines for the control of tick infestations and pathogen transmission is essential for prevention and control of tick-borne diseases worldwide. Recently, the application of omics technologies has advanced the identification of tick protective antigens. However, other factors such as vaccine formulation and implementation need to be addressed, and tick vaccine modeling will contribute to improve the efficacy of vaccination strategies.: In this review, we summarized current information on tick vaccine correlates of protection and modeling, and proposed new approaches to improve vaccine evaluation and implementation using as a proof-of-concept the -Crimean-Congo hemorrhagic fever virus model due to its high mortality rate and potentially growing impact on human health.: Vaccines are required as an effective and environmentally sound intervention for the control of tick-borne diseases affecting human and animal health worldwide. Despite recent advances in the identification of candidate tick protective antigens, research on vaccine formulation and implementation need to be addressed to improve tick vaccine control efficacy. As shown here, modeling of the vaccination strategies against ticks and transmitted pathogens will contribute to vaccine development by guiding the selection of appropriate antigen combinations, target hosts, and vaccination time schedule.