Palomar Ana M, Portillo Aránzazu, Santibáñez Sonia, García-Álvarez Lara, Muñoz-Sanz Agustín, Márquez Francisco J, Romero Lourdes, Eiros José M, Oteo José A
Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Departamento de Enfermedades Infecciosas, Hospital San Pedro-CIBIR, Logroño, Spain.
Servicio de Patología Infecciosa, Hospital Universitario de Badajoz, Badajoz, Spain.
Enferm Infecc Microbiol Clin. 2017 Jun-Jul;35(6):344-347. doi: 10.1016/j.eimc.2017.01.009. Epub 2017 Mar 11.
Crimean-Congo hemorrhagic fever (CCHF) is a viral disease, mainly transmitted through tick bite, of great importance in Public Health. In Spain, Crimean-Congo hemorrhagic fever virus (CCHFV) was detected for the first time in 2010 in Hyalomma lusitanicum ticks collected from deer in Cáceres. The aim of this study was to investigate the presence of CCHFV in ticks from Cáceres, and from other Spanish areas, and to evaluate the presence of antibodies against the virus in individuals exposed to tick bites.
A total of 2053 ticks (1333 Hyalomma marginatum, 680 H. lusitanicum and 40 Rhipicephalus bursa) were analyzed using molecular biology techniques (PCR) for CCHFV detection. The determination of specific IgG antibodies against CCHFV in 228 serum samples from humans with regular contact with ticks (at risk of acquiring the infection) was performed by indirect immunofluorescence assay.
The CCHFV was not amplified in ticks, nor were antibodies against the virus found in the serum samples analyzed.
The absence of the CCHFV in the ticks studied and the lack of antibodies against the virus in individuals exposed to tick bites would seem to suggest a low risk of acquisition of human infection by CCHFV in Spain.
克里米亚-刚果出血热（CCHF）是一种主要通过蜱叮咬传播的病毒性疾病，对公共卫生至关重要。2010年，在西班牙卡塞雷斯从鹿身上采集的卢氏璃眼蜱中首次检测到克里米亚-刚果出血热病毒（CCHFV）。本研究的目的是调查卡塞雷斯以及西班牙其他地区蜱中CCHFV的存在情况，并评估暴露于蜱叮咬的个体中针对该病毒的抗体存在情况。
共分析了2053只蜱（1333只边缘璃眼蜱、680只卢氏璃眼蜱和40只柏氏扇头蜱），采用分子生物学技术（PCR）检测CCHFV。通过间接免疫荧光试验对228份来自经常接触蜱（有感染风险）的人类血清样本中针对CCHFV的特异性IgG抗体进行测定。
在所研究的蜱中未扩增出CCHFV，在所分析的血清样本中也未发现针对该病毒的抗体。
在所研究的蜱中未发现CCHFV，且暴露于蜱叮咬的个体中缺乏针对该病毒的抗体，这似乎表明在西班牙人类感染CCHFV的风险较低。
