Tisdale M J, Brennan R A
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Br J Cancer. 1988 Nov;58(5):580-3. doi: 10.1038/bjc.1988.263.
A comparison has been made between the ability of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) to prevent weight loss induced by the cachexia-inducing colon adenocarcinoma (MAC16) and to reduce tumour size. There was no difference in calorie consumption or nitrogen intake between the various groups. When compared with a normal control high carbohydrate, low fat diet, animals fed MCT showed a reduced weight loss and a marked reduction in tumour size. In contrast neither weight loss nor tumour size differed significantly from the controls in animals fed the LCT diet. An elevated plasma level of 3-hydroxybuturate was found only in the animals fed the MCT diets. Administration of LCT caused an increase in the plasma level of FFA, which was not observed in the MCT group. These results suggest that diets containing MCT would provide the best ketogenic regime to reverse the weight loss in cancer cachexia with a concomitant reduction in tumour size.
对长链甘油三酯（LCT）和中链甘油三酯（MCT）预防由恶病质诱导性结肠腺癌（MAC16）引起的体重减轻以及减小肿瘤大小的能力进行了比较。各实验组之间的热量消耗或氮摄入量没有差异。与正常对照的高碳水化合物、低脂肪饮食相比，喂食MCT的动物体重减轻减少，肿瘤大小显著减小。相比之下，喂食LCT饮食的动物的体重减轻和肿瘤大小与对照组相比均无显著差异。仅在喂食MCT饮食的动物中发现血浆3-羟基丁酸水平升高。给予LCT导致血浆游离脂肪酸（FFA）水平升高，而MCT组未观察到这种情况。这些结果表明，含MCT的饮食将提供最佳的生酮方案，以扭转癌症恶病质中的体重减轻，并同时减小肿瘤大小。
