Ellerin B E, Demandante C G N, Martins J T
UT Health East Texas, Tyler, TX 75701, USA.
SLLC Oncology, P.L.C., Tyler, TX 75701, USA.
Cancer Radiother. 2020 Jun;24(3):226-246. doi: 10.1016/j.canrad.2020.01.001. Epub 2020 Mar 17.
We report the case of an 84-year-old woman with poorly differentiated non-small cell carcinoma of the right parotid who presented with headache, was found to have a primary right parotid gland cancer as well as metastatic disease, and underwent palliative radiotherapy to the primary site. The patient received no chemotherapy or immunotherapy, but both the primary site and several non-irradiated foci in the lungs regressed or completely resolved. The patient remained free of disease for about one year before progression. The case is a rare instance of abscopal regression of metastatic disease in the absence of pharmacologic immunomodulation. A literature review surveys the history of the abscopal effect of radiation therapy, attempts to understand the mechanisms of its successes and failures, and points to new approaches that can inform and improve the outcomes of radioimmunotherapy.
我们报告了一例84岁女性患者，患有右腮腺低分化非小细胞癌，表现为头痛，被发现患有原发性右腮腺癌及转移性疾病，并对原发部位进行了姑息性放疗。该患者未接受化疗或免疫治疗，但原发部位及肺部几个未接受放疗的病灶均出现退缩或完全消退。患者在病情进展前约一年无疾病复发。该病例是在没有药物免疫调节的情况下转移性疾病发生远隔效应消退的罕见实例。文献综述回顾了放射治疗远隔效应的历史，试图理解其成功与失败的机制，并指出了可指导和改善放射免疫治疗结果的新方法。
