Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.
Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.
Development. 2020 Mar 19;147(6):dev180844. doi: 10.1242/dev.180844.
Understanding how to promote organ and appendage regeneration is a key goal of regenerative medicine. The frog, , can achieve both scar-free healing and tissue regeneration during its larval stages, although it predominantly loses these abilities during metamorphosis and adulthood. This transient regenerative capacity, alongside their close evolutionary relationship with humans, makes an attractive model to uncover the mechanisms underlying functional regeneration. Here, we present an overview of as a key model organism for regeneration research and highlight how studies of have led to new insights into the mechanisms governing regeneration.
了解如何促进器官和附属物的再生是再生医学的一个关键目标。青蛙 在其幼虫阶段既能实现无疤痕愈合，又能实现组织再生，尽管在变态和成年阶段它主要失去了这些能力。这种短暂的再生能力，以及它们与人类的密切进化关系，使 成为揭示功能再生背后机制的有吸引力的模型。在这里，我们概述了 作为再生研究的关键模式生物，并强调了对 的研究如何导致对控制再生的机制的新见解。
