Postgraduate Program in Genomic Sciences, Science and Technology School, Autonomous University of Mexico City, Mexico City, CP 03100, Mexico.
Biochemistry Department, Center for Research and Advanced Studies, National Polytechnic Institute of Mexico), Mexico City, CP 07360, Mexico.
Int J Mol Med. 2024 May;53(5). doi: 10.3892/ijmm.2024.5368. Epub 2024 Mar 22.
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy. In addition, novel potential interactions between circRNAs expressed in renal cells exposed to high‑glucose concentrations and the transcription factors c‑Jun and c‑Fos are reported.
环状 RNA（circRNAs）是一种非编码的单链共价闭合 RNA 分子，被认为在转录和转录后水平上作为基因表达的重要调节剂。这些分子已被牵连到多种人类疾病的发生和进展中，范围从癌症到炎症和代谢疾病，包括糖尿病及其血管并发症。本文旨在综述 circRNAs 的生物发生和功能的最新知识，以及它们在与糖尿病肾病相关的细胞过程中的作用。此外，还报道了在高葡萄糖浓度下暴露的肾细胞中表达的 circRNAs 与转录因子 c-Jun 和 c-Fos 之间的新的潜在相互作用。
