Nomoto Tatsuya, Iizaka Shinji
Tatsuya Nomoto, MD, is Assistant Director of the Hospital, Department of Rehabilitation Medicine, Minamino Hospital, Tokyo, Japan. Shinji Iizaka, PhD, RN, PHN, is Associate Professor, School of Nutrition, College of Nursing and Nutrition, Shukutoku University, Chiba, Japan. Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Acknowledgments: The authors thank the staff at Eisei and Minamino Hospitals for their assistance with skin measurements. Financial support was provided by Nutri Co Ltd, which paid for the test products in addition to lending researchers the measuring equipment. Dr Nomoto discloses that he has received honoraria for lectures from Nutri Co, Ltd. The authors have disclosed no other financial relationships related to this article. Submitted September 4, 2019; accepted in revised form October 11, 2019.
Adv Skin Wound Care. 2020 Apr;33(4):186-191. doi: 10.1097/01.ASW.0000655492.40898.55.
The purpose of this randomized open-label study was to investigate the effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity.
The study protocol was registered at the UMIN Clinical Trials Registry (UMIN 000027347). Once-a-day oral administration of a nutrition supplement containing collagen peptides (10.0 g) was instituted in 39 inpatients 65 years or older who were assigned to either the intervention or the control group using a block-randomization design. Stratum corneum hydration and skin elasticity were measured at baseline and at 2, 4, 6, and 8 weeks after the start of the intervention.
Mean stratum corneum hydration was significantly increased from 43.7 at baseline to 51.7 at postintervention week 8 in the intervention group (P = .001). Differences in skin elasticity from baseline were significant at postintervention week 6 (P = .026) and week 8 (P = .049).
Oral nutrition supplements containing collagen peptides may reduce skin vulnerability in older adults and thus prevent conditions such as skin tears.
本随机开放标签研究旨在调查含胶原蛋白肽的口服营养补充剂对角质层水合作用和皮肤弹性的影响。
该研究方案已在日本大学医学情报网络临床试验注册中心注册（UMIN 000027347）。采用区组随机化设计，将39名65岁及以上的住院患者分为干预组或对照组，每天口服一次含胶原蛋白肽的营养补充剂（10.0 g）。在基线以及干预开始后的第2、4、6和8周测量角质层水合作用和皮肤弹性。
干预组的平均角质层水合作用从基线时的43.7显著增加至干预后第8周的51.7（P = .001）。干预后第6周（P = .026）和第8周（P = .049）时，皮肤弹性与基线的差异具有统计学意义。
含胶原蛋白肽的口服营养补充剂可能会降低老年人皮肤的脆弱性，从而预防诸如皮肤撕裂等情况。
