Lacoste L, Bartolucci S, Lapointe J
Département de biochimie, Faculté de médecine, Université Laval, Québec, Canada.
Can J Physiol Pharmacol. 1988 Sep;66(9):1135-8. doi: 10.1139/y88-186.
The mechanism by which pentylenetetrazole provokes convulsions in animals has been investigated by measuring its influence in vitro on the activities of several enzymes of glutamate metabolism in rat brain homogenates. Pentylenetetrazole does not affect the specific activities of glutamine synthetase, glutaminase, or glutamate decarboxylase; it inhibits those of glutamate dehydrogenase and aspartate aminotransferase, and stimulates that of gamma-aminobutyric acid (GABA) aminotransferase. The overall consequence of the action of pentylenetetrazole on the activities of these enzymes should be an increase in the concentration of glutamate and a decrease in that of GABA. This modulation of glutamate and GABA metabolism by pentylenetetrazole could contribute to the triggering of convulsions.
通过测量戊四氮在体外对大鼠脑匀浆中几种谷氨酸代谢酶活性的影响，对戊四氮在动物中诱发惊厥的机制进行了研究。戊四氮不影响谷氨酰胺合成酶、谷氨酰胺酶或谷氨酸脱羧酶的比活性；它抑制谷氨酸脱氢酶和天冬氨酸转氨酶的活性，并刺激γ-氨基丁酸（GABA）转氨酶的活性。戊四氮对这些酶活性作用的总体结果应该是谷氨酸浓度升高和GABA浓度降低。戊四氮对谷氨酸和GABA代谢的这种调节可能有助于惊厥的触发。
