Khanna N, Garg A, Sharma K K, Khosla R
Department of Pharmacology, University College of Medical Sciences & G.T.B. Hospital, 110 095 Delhi.
Indian J Clin Biochem. 1997 Dec;12(1):86-90. doi: 10.1007/BF02867963.
In the present study which was aimed to see the effect of zinc on pentylenetetrazole induced convulsive threshold in rats we found that zinc sulfate 100 μg intracerebroventricularly) and pentylenetetrazole (50 mg/kg intraperitoneally) produced dose related seizure activity; however, pretreatment with zinc decreased the threshold, increased the severity, incidence of multiple seizures and total duration of pentylenetetrazole induced seizures. Diazepam (5 mg/kg intraperitoneally) pretreatment increased the threshold and lowered the incidence of convulsions in zinc induced seizures which further confirms that the convulsive effect of zinc is through inhibition of gamma aimino butyric acid.
在本研究中，旨在观察锌对戊四氮诱导的大鼠惊厥阈值的影响，我们发现，脑室内注射100μg硫酸锌和腹腔注射50mg/kg戊四氮可产生剂量相关的癫痫发作活动；然而，锌预处理降低了阈值，增加了严重程度、多次癫痫发作的发生率以及戊四氮诱导癫痫发作的总持续时间。地西泮（腹腔注射5mg/kg）预处理提高了阈值，并降低了锌诱导癫痫发作时的惊厥发生率，这进一步证实锌的惊厥作用是通过抑制γ-氨基丁酸实现的。
