Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
J Cell Mol Med. 2020 Jul;24(14):8262-8265. doi: 10.1111/jcmm.15275. Epub 2020 May 19.
An ongoing outbreak of viral pneumonia was caused by a novel coronavirus in China in 2019. By March 19, over 200 thousand confirmed cases of SARS-CoV-2 infection and over 9000 deaths have been reported throughout the world. For this infectious disease, nucleic acid detection is still the gold standard for pathogenic detection. However, nucleic acid detection takes a long time and has relatively high "false negative"; therefore, we need urgently a convenient and accurate detection method to make up for this deficiency. In this article, we will show such technical characteristics of lgM/lgG serum antibody detection, compared with nucleic acid detection.
2019 年中国发生了新型冠状病毒引起的病毒性肺炎疫情。截至 2020 年 3 月 19 日，全球已报告超过 20 万例新型冠状病毒感染确诊病例，死亡人数超过 9000 例。对于这种传染病，核酸检测仍然是病原检测的金标准。然而，核酸检测耗时较长，且具有相对较高的“假阴性”；因此，我们迫切需要一种方便、准确的检测方法来弥补这一不足。本文将展示 lgM/lgG 血清抗体检测与核酸检测相比的技术特点。
