Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
J Clin Lab Anal. 2020 Jul;34(7):e23301. doi: 10.1002/jcla.23301. Epub 2020 Mar 20.
The information on mortality after an acute stroke patient is still limited.
The aim of this study was to investigate the prognostic potential of procalcitonin (PCT) serum levels in acute ischemic stroke.
A total of 748 patients were enrolled in this study. Prognostic potential of PCT was evaluated by Kaplan-Meier analysis and multivariable Cox hazard regression analyses.
Procalcitonin levels were found to be significantly higher in acute ischemic stroke patients who died in 30 days than those who survived. Univariate logistic regression analysis showed that PCT was significantly associated with 30-day mortality, and Cox regression analysis revealed that PCT was a strong predictor of 30-day overall mortality. Kaplan-Meier analysis revealed that overall cumulative 30-day mortality was significantly higher in those with PCT levels >1.5 ng/mL when compared to those with PCT levels <1.5 ng/mL.
Procalcitonin is a significant independent prognostic marker of 30-day mortality after the one set of acute ischemic stroke.
急性脑卒中患者的死亡率信息仍然有限。
本研究旨在探讨降钙素原（PCT）血清水平对急性缺血性脑卒中的预后预测价值。
本研究共纳入 748 例患者。通过 Kaplan-Meier 分析和多变量 Cox 风险回归分析评估 PCT 的预后预测价值。
在 30 天内死亡的急性缺血性脑卒中患者的 PCT 水平明显高于存活的患者。单因素 logistic 回归分析显示，PCT 与 30 天死亡率显著相关，Cox 回归分析显示 PCT 是 30 天总死亡率的强预测因子。Kaplan-Meier 分析显示，与 PCT 水平<1.5ng/mL 的患者相比，PCT 水平>1.5ng/mL 的患者总体累积 30 天死亡率显著更高。
在急性缺血性脑卒中患者中，降钙素原是 30 天死亡率的一个显著独立预后标志物。
