Master's Program in Environment and Health, University of Cuiabá, Cuiabá 78065-700, Brazil.
Int J Environ Res Public Health. 2020 Mar 18;17(6):1984. doi: 10.3390/ijerph17061984.
Previous studies have shown that high levels of air pollutants may increase activity of systemic lupus erythematosus (SLE). The aim of this study is to analyze the association between pollutants originating from the Brazilian Legal Amazon and SLE activity. This is a retrospective longitudinal cohort study with patients with SLE in the General Hospital in Cuiabá, Brazil. The association with SLE activity was measured using the SLE disease activity index (SLEDAI) and data on air quality-PM and CO, published on the websites of the State Department of Environment and the Center for Weather Forecasting and Climate Studies. To assess the effect of daily concentrations of pollutants on SLEDAI scores, the generalized estimation equation (GEE) model was used. A total of 32 female patients were assessed, in 96 doctor's appointments. The average SLEDAI score was 6 points (±5.05). GEE showed an association of disease activity with both higher rates of wildfires ( = 0.021) and average CO rate ( = 0.013), but there was no statistical association between particulate levels and SLE activity. The results suggest that variations in air pollution are associated with the activity of autoimmune rheumatic diseases.
先前的研究表明，高水平的空气污染物可能会增加系统性红斑狼疮（SLE）的活动度。本研究旨在分析源自巴西法定亚马逊地区的污染物与 SLE 活动之间的关联。这是一项回顾性纵向队列研究，研究对象为巴西库亚巴总医院的 SLE 患者。使用 SLE 疾病活动指数（SLEDAI）来衡量与 SLE 活动的关联，空气质量数据-PM 和 CO，发表在州环境部门和天气预报与气候研究中心的网站上。为了评估污染物每日浓度对 SLEDAI 评分的影响，使用了广义估计方程（GEE）模型。共评估了 32 名女性患者的 96 次就诊情况。平均 SLEDAI 评分为 6 分（±5.05）。GEE 显示疾病活动度与野火发生率较高（ = 0.021）和平均 CO 率（ = 0.013）相关，但颗粒物水平与 SLE 活动之间无统计学关联。结果表明，空气污染的变化与自身免疫性风湿性疾病的活动度有关。
