Sauerbier I
Department of Anatomy, Hannover Medical School, F.R.G.
Chronobiol Int. 1988;5(3):211-6. doi: 10.3109/07420528809079562.
Circadian influences on growth and development in response to ethanol were studied in mice. On gestational day 10, pregnant animals received a single intraperitoneal injection of ethanol with the following dose levels: 1.0, 2.5 or 4.0 g/kg at one of four circadian phases (0700, 1300, 1900 or 0100 hr). 48 hrs after injection the embryonic weight and length, protein and DNA content and placental weight and protein were determined. Ethanol-related intrauterine growth retardation were shown to be dose- and circadian phase-dependent, the greatest susceptibility being seen during the dark phase. The variations observed are discussed with regard to changes in drug metabolism and tissue sensitivity.
研究了昼夜节律对小鼠乙醇诱导的生长发育的影响。在妊娠第10天，怀孕小鼠在四个昼夜节律阶段（07:00、13:00、19:00或01:00）之一接受单次腹腔注射乙醇，剂量水平如下：1.0、2.5或4.0 g/kg。注射后48小时，测定胚胎的重量和长度、蛋白质和DNA含量以及胎盘的重量和蛋白质。结果表明，乙醇相关的宫内生长迟缓具有剂量和昼夜节律阶段依赖性，在黑暗阶段易感性最高。结合药物代谢和组织敏感性的变化对观察到的差异进行了讨论。
