Laille M, Brethes B, Moreau J P, Pillot J
Institut Pasteur de Nouméa, Nouvelle-Calédonie.
Bull Soc Pathol Exot Filiales. 1988;81(4):673-8.
A prophylaxis trial of hepatitis B at birth was carried out in New Caledonia. Ninety-nine newborns from women carrying hepatitis B antigen during pregnancy were immunized. The prophylaxis protocol was as follows: anti-HBs immunoglobulin and the first dose of vaccine at birth if the mother was HBe Ag+ or HBe Ag- without anti-HBe, only vaccination if the mother showed anti-HBe antibodies. 73.8% had anti-HBs antibodies when checked at 6 months; at the age of one year, this figure was 60.4%. Four months after the booster injection, 68.3% were anti-HBs positive. Among all these children, three of them were born to HBe Ag+ mothers became HBs Ag/HBe Ag positive. The control group studied showed that mother-infant vertical transmission was not the only route of contamination in children in New Caledonia.
在新喀里多尼亚进行了一项关于出生时乙肝预防的试验。对99名母亲在孕期携带乙肝抗原的新生儿进行了免疫接种。预防方案如下：如果母亲是HBe Ag阳性或HBe Ag阴性且无抗HBe，则在出生时注射抗-HBs免疫球蛋白和第一剂疫苗；如果母亲显示有抗-HBe抗体，则仅进行疫苗接种。6个月检查时，73.8%的儿童有抗-HBs抗体；1岁时，这一数字为60.4%。加强注射4个月后，68.3%的儿童抗-HBs呈阳性。在所有这些儿童中，有3名母亲为HBe Ag阳性的儿童变成了HBs Ag/HBe Ag阳性。所研究的对照组表明，母婴垂直传播并非新喀里多尼亚儿童感染的唯一途径。
