Department of Neurology, University of Alabama at Birmingham, United States.
National Center for Toxicological Research, United States Food and Drug Administration, United States.
Regul Toxicol Pharmacol. 2020 Jun;113:104642. doi: 10.1016/j.yrtph.2020.104642. Epub 2020 Mar 18.
During the 25 years since the US Congress passed the Dietary Supplement Health and Education Act (DSHEA), the law that transformed the US Food and Drug Administration's (FDA's) authority to regulate dietary supplements, the dietary supplement market has grown exponentially. Retail sales of herbal products, a subcategory of dietary supplements, have increased 83% from 2008 to 2018 ($4.8 to $8.8 billion USD). Although consumers often equate "natural" with "safe", it is well recognized by scientists that constituents in these natural products (NPs) can result in toxicity. Additionally, when NPs are co-consumed with pharmaceutical agents, the precipitant NP can alter drug disposition and drug delivery, thereby enhancing or reducing the therapeutic effect of the object drug(s). With the widespread use of NPs, these effects can be underappreciated. We present a summary of a symposium presented at the Annual Meeting of the Society of Toxicology 2019 (12 March 2019) that discussed potential toxicities of NPs alone and in combination with drugs.
自 25 年前美国国会通过《膳食补充剂健康与教育法案》（DSHEA）以来，改变了美国食品和药物管理局（FDA）监管膳食补充剂的权力，膳食补充剂市场呈指数级增长。草药产品（膳食补充剂的一个亚类）的零售额从 2008 年到 2018 年增长了 83%（从 48 亿美元增至 88 亿美元）。尽管消费者通常将“天然”与“安全”等同起来，但科学家们深知这些天然产品（NPs）中的成分可能会导致毒性。此外，当 NPs 与药物同时服用时，引发毒性的 NP 会改变药物的处置和药物传递，从而增强或降低目标药物的治疗效果。随着 NPs 的广泛使用，这些影响可能被低估了。我们总结了 2019 年毒理学学会年会（2019 年 3 月 12 日）上的一个专题研讨会，该研讨会讨论了 NPs 单独使用和与药物联合使用的潜在毒性。
