Flores-Flores Angélica, Estrada-Soto Samuel, Mulero-Navarrete Marlen Miuler, Hernández-Pando Rogelio, Enciso-Díaz Oswaldo Javier, Arias-Durán Luis, Bazán-Perkins Blanca, Villalobos-Molina Rafael
Laboratorio de Inmunofarmacología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Monterrey 64700, Mexico.
Pharmaceuticals (Basel). 2025 Jun 12;18(6):881. doi: 10.3390/ph18060881.
Mexico, one of the world's most biodiverse countries, holds a rich tradition of using medicinal plants to manage chronic diseases such as type 2 diabetes and hypertension. Despite their historical significance, the scientific validation of these plants' mechanisms and safety remains limited. Natural products have shown potential in improving insulin sensitivity, reducing insulin resistance, and promoting vasodilation. , a native orchid, is believed to possess therapeutic properties, yet its pharmacological effects are unexplored. : The current investigation is aimed to bridge traditional knowledge and scientific evidence by investigating the antidiabetic, vasodilatory and antihypertensive activities of a 1:1 dichloromethane and methanol extract from bulbs, alongside an evaluation of its pharmacological safety. Antidiabetic effects of the extract were evaluated in a non-insulin-dependent mouse model using a 100 mg/kg dose. Vasodilatory activity was assessed ex vivo using rat aortic rings, exploring its mechanism through calcium channel blockade. Antihypertensive effects were evaluated in spontaneously hypertensive rats, while acute and subacute toxicity tests were conducted in a murine model. : The extract significantly reduced glycemia between 1, 3, 5, and 7 h compared to the positive control (* = 0.04, *** < 0.001) and induced vasorelaxation but showed no antihypertensive effects in vivo. Toxicity tests indicated no severe damage, though elevated transaminase activity and increased liver weight were observed. Histopathological analysis revealed minimal hepatocellular lesions with active regeneration. : demonstrates potential in the discovery of active metabolites to treat diabetes, with significant hypoglycemic and vasorelaxant effects and promising pharmacological safety. Further research is needed to fully understand its therapeutic applications and ensure its safe integration.
墨西哥是世界上生物多样性最丰富的国家之一，有着使用药用植物治疗2型糖尿病和高血压等慢性病的悠久传统。尽管这些植物具有历史意义，但其作用机制和安全性的科学验证仍然有限。天然产物已显示出改善胰岛素敏感性、降低胰岛素抵抗和促进血管舒张的潜力。一种本土兰花，被认为具有治疗特性，但其药理作用尚未得到探索。：目前的研究旨在通过研究来自[兰花名称]鳞茎的二氯甲烷和甲醇1:1提取物的抗糖尿病、血管舒张和抗高血压活性，以及评估其药理安全性，来弥合传统知识与科学证据之间的差距。在非胰岛素依赖型小鼠模型中使用100mg/kg剂量评估提取物的抗糖尿病作用。使用大鼠主动脉环离体评估血管舒张活性，通过钙通道阻滞探索其机制。在自发性高血压大鼠中评估抗高血压作用，同时在小鼠模型中进行急性和亚急性毒性试验。：与阳性对照相比，提取物在1、3、5和7小时显著降低血糖（*P = 0.04，***P < 0.001），并诱导血管舒张，但在体内未显示抗高血压作用。毒性试验表明没有严重损伤，尽管观察到转氨酶活性升高和肝脏重量增加。组织病理学分析显示肝细胞损伤最小且有活跃再生。：[兰花名称]在发现治疗糖尿病的活性代谢物方面显示出潜力，具有显著的降血糖和血管舒张作用以及良好的药理安全性。需要进一步研究以充分了解其治疗应用并确保其安全应用。
