Amway Corporation, Buena Park, California, USA.
Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Regul Toxicol Pharmacol. 2023 Oct;144:105471. doi: 10.1016/j.yrtph.2023.105471. Epub 2023 Aug 19.
Interest in botanicals, particularly as dietary supplement ingredients, is growing steadily. This growth, and the marketing of new ingredients and combination products as botanical dietary supplements, underscores the public health need for a better understanding of potential toxicities associated with use of these products. This article and accompanying template outline the resources to collect literature and relevant information to support the design of botanical toxicity studies. These resources provide critical information related to botanical identification, characterization, pre-clinical and clinical data, including adverse effects and interactions with pharmaceuticals. Toxicologists using these resources should collaborate with pharmacognosists and/or analytical chemists to enhance knowledge of the botanical material being tested. Overall, this guide and resource list is meant to help locate relevant information that can be leveraged to inform on decisions related to toxicity testing of botanicals, including the design of higher quality toxicological studies.
人们对植物药的兴趣与日俱增，尤其是将其作为膳食补充剂的成分。这种增长，以及新成分和组合产品作为植物药膳食补充剂的营销，凸显了公众对更好地了解使用这些产品相关潜在毒性的需求。本文和附带的模板概述了收集文献和相关信息的资源，以支持植物毒性研究的设计。这些资源提供了与植物鉴定、特征描述、临床前和临床数据相关的关键信息，包括不良反应和与药物的相互作用。毒理学家使用这些资源时，应与生药学专家和/或分析化学家合作，以增强对正在测试的植物材料的了解。总的来说，本指南和资源清单旨在帮助找到相关信息，以便为植物毒性测试的决策提供信息，包括更高质量毒理学研究的设计。
