Katuri Medical College and Hospital, Katuri College of Nursing, Guntur, AP, India.
Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Int Urol Nephrol. 2020 May;52(5):917-921. doi: 10.1007/s11255-020-02417-x. Epub 2020 Mar 20.
Osteopontin (OPN) is evolving as a novel biomarker of injury, overall survival and renal outcome in critically ill patients with acute kidney injury (AKI), requiring renal replacement therapy.
We performed a prospective study on 35 consecutive patients of acute kidney injury requiring renal replacement therapy (AKIN stage 3). OPN levels were measured in the patients and in the controls. The relation between OPN and the severity of illness and its effect on the AKI and renal outcome were studied.
There was a statistically significant elevation of OPN in patients of AKIN stage 3 in comparison to healthy controls (p = 0.001). The Sequential Organ Function Assessment (SOFA) scores were found to be higher in septic group in comparison to non-septic group and it was statistically significant (p = 0.014). There was significant correlation between SOFA scoring and OPN levels suggesting its association with severity (r = 0.382, p = 0.023).
In our study, OPN was found to be a valuable marker of severity of injury, its association with sepsis and renal recovery, in patients with acute kidney injury needing renal replacement therapy.
骨桥蛋白（OPN）正在成为危重病急性肾损伤（AKI）患者损伤、总生存率和肾脏预后的新型生物标志物，这些患者需要肾脏替代治疗。
我们对 35 名连续的急性肾损伤需要肾脏替代治疗（AKIN 3 期）的患者进行了前瞻性研究。在患者和对照组中测量了 OPN 水平。研究了 OPN 与疾病严重程度之间的关系及其对 AKI 和肾脏结局的影响。
与健康对照组相比，AKIN 3 期患者的 OPN 水平明显升高（p=0.001）。与非脓毒症组相比，脓毒症组的序贯器官衰竭评估（SOFA）评分更高，且具有统计学意义（p=0.014）。SOFA 评分与 OPN 水平之间存在显著相关性，提示其与严重程度有关（r=0.382，p=0.023）。
在我们的研究中，OPN 被发现是急性肾损伤需要肾脏替代治疗的患者损伤严重程度、与脓毒症和肾脏恢复的关联的有价值的标志物。
